April 21, 2025
NFL Week 15 Picks Against the Spread

NFL Week 15 Picks Against the Spread

NFL Week 15 is here. Picking NFL games straight up is hard enough, but picking against the spread is even tougher. Here are the NFL week 15 picks against the spread. (Spreads are from Tallysight as of Tuesday morning)

Last Week: 5-8

Season: 114-88-4

Thursday Night Football

Los Angeles Rams at San Francisco 49ers (-2.5)

The Rams just won one of the games of the year against the Bills, showing great offensive firepower. While the 49ers looked good against the Bears, that may be more about Chicago than themselves. Los Angeles can pull off the upset and stay in the playoff race.

Pick: Rams

Sunday Afternoon

Baltimore Ravens (-14.5) at New York Giants

Baltimore is coming off of a bye and will be fresh for the Giants, who can’t consistently move the football. The Ravens should take care of business.

Pick: Ravens

New York Jets (-3.5) at Jacksonville Jaguars

Jacksonville got a win without Trevor Lawrence, but it was over the Titans. Aaron Rodgers played well against the Dolphins and can take advantage of the Jaguars’ defense

Pick: Jets

Washington Commanders (-7.5) at New Orleans Saints

The Commanders are coming off a bye and will want to win to keep pace in the NFC playoff race. New Orleans has injury issues at the quarterback position with Derek Carr getting hurt last week against the Giants.

Pick: Commanders

Cincinnati Bengals (-4.5) at Tennessee Titans

Cincinnati will be on a short week, but their offense is clicking. Tennessee may not be equipped to take advantage of the Bengals’ lackluster defense after they struggled to score on the Jaguars.

Pick: Bengals

Miami Dolphins at Houston Texans (-2.5)

The Dolphins’ offense is coming together and they are still alive in the AFC playoff picture if they keep winning. Houston had a bye last week, but has been struggling in their last few games before that. Miami’s offense an create problems for Houston.

Pick: Dolphins

Kansas City Chiefs (-4.5) at Cleveland Browns

Kansas City hasn’t been good against the spread this season which has resulted in spreads coming down. The Chiefs can win this one and cover on the road against the Browns, who have some turnover issues.

Pick: Chiefs

Dallas Cowboys at Carolina Panthers (-1.5)

Carolina is playing much better as the result of Bryce Young’s emergence. They have struggled to win the last three games. This can be a close one against the Cowboys, but Dallas can come out on top because of their defense limiting the Panthers.

Pick: Cowboys

Sunday Evening

New England Patriots at Arizona Cardinals (-6.5)

The Cardinals have struggled with a tough schedule the last three weeks. They need a game to get things back on track and can win this one to stay on track in the NFC playoff race.

Pick: Cardinals

Tampa Bay Buccaneers at Los Angeles Chargers (-2.5)

Tampa Bay has fought this season, but sometimes has issues sustaining offense. The Chargers’ defense is much improved this season and should be able to win a low-scoring game.

Pick: Chargers

Buffalo Bills at Detroit Lions (-1.5)

The Bills’ defense really struggled against the Rams last week, so they will likely have issues with the Lions this week. Detroit played on Thursday in week 14 and the extra time to prepare will help them win and cover at home.

Pick: Lions

Indianapolis Colts at Denver Broncos (-4.5)

Denver’s defense has been playing great this season. They can limit an Anthony Richardson-led offense and possibly force some turnovers. Bo Nix and the offense can put up some points to help cover.

Pick: Broncos

Pittsburgh Steelers at Philadelphia Eagles (-5.5)

The Eagles nearly lost to the Panthers last week and seem to have some locker-room issues. They can still beat the Steelers, but it might be close unless they get things figured out.

Pick: Steelers

Sunday Night Football

Green Bay Packers (-3) at Seattle Seahawks

Green Bay lost by a field goal to Detroit last week, ending a hot streak. Seatle is on a hot streak of their own winning their last four games. Their defense has been particularly impressive and they can protect their home turf.

Pick: Seahawks

Monday Night Football

Chicago Bears at Minnesota Vikings (-7)

Chicago fired their head coach, but things still look bad, as they were trounced by the 49ers. Minnesota has continued to play well, as Sam Darnold had a good game against the Falcons, improving the Vikings’ record to 11-2.

Pick: Vikings

Atlanta Falcons (-4.5) at Las Vegas Raiders

The Raiders lost Gardner Minshew and now Aidan O’Connell for the season. Their offense is a mess. While the Falcons are struggling, they should be able to win and cover against the Raiders.

Pick: Falcons

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